Factors Associated With 5- and 10-Year Survival After Intestinal Transplantation in Infants and Children.
J Pediatr Gastroenterol Nutr
; 71(5): 617-623, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-33093368
ABSTRACT
OBJECTIVES:
Intestinal transplantation is an option for permanent intestinal failure with parenteral nutrition intolerance. We sought to determine long-term intestinal graft survival in pediatric patients at our center and to identify factors influencing survival.METHODS:
Retrospective chart review of 86 patients transplanted between 2003 and 2013, targeting potential explanatory variables related to demographics, perioperative factors, and postoperative complications.RESULTS:
Intestinal graft survival was 71% and 65% after 5 and 10 years, respectively. Five-year graft survival was attained in 79% of patients with a history of anatomic intestinal failure compared with 45% with functional intestinal failure (Pâ=â0.0055). Compared with nonsurvival, 5-year graft survival was also associated with reduced incidences of graft-versus-host disease (2% vs 16%, Pâ=â0.0237), post-transplant lymphoproliferative disorder (3% vs 24%, Pâ=â0.0067), and de novo donor-specific antibodies (19% vs 57%, Pâ=â0.0451) plus a lower donor-recipient weight ratio (median 0.727 vs 0.923, Pâ=â0.0316). Factors not associated with 5-year intestinal graft survival included graft rejection of any severity and inclusion of a liver graft. Factors associated with graft survival at 10 years were similar to those at 5 years.CONCLUSIONS:
In our experience, outcomes in pediatric intestinal transplantation have improved substantially for anatomic but not functional intestinal failure. Graft survival depends on avoidance of severe infectious and immunological complications including GVHD, whereas inclusion of a liver graft provides no obvious survival benefit. Reduced success with functional intestinal failure may reflect inherently increased susceptibility to complications in this group.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Fígado
/
Rejeição de Enxerto
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
/
Infant
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Ano de publicação:
2020
Tipo de documento:
Article