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Identification of the hydantoin alkaloids parazoanthines as novel CXCR4 antagonists by computational and in vitro functional characterization.
Vitale, Rosa Maria; Thellung, Stefano; Tinto, Francesco; Solari, Agnese; Gatti, Monica; Nuzzo, Genoveffa; Ioannou, Efstathia; Roussis, Vassilios; Ciavatta, Maria Letizia; Manzo, Emiliano; Florio, Tullio; Amodeo, Pietro.
Afiliação
  • Vitale RM; Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy.
  • Thellung S; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy.
  • Tinto F; Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy.
  • Solari A; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy.
  • Gatti M; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy.
  • Nuzzo G; Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy.
  • Ioannou E; Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
  • Roussis V; Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
  • Ciavatta ML; Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy.
  • Manzo E; Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy. Electronic address: emanzo@icb.cnr.it.
  • Florio T; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy; IRCCS Policlinico San Martino, 16132 Genova, Italy. Electronic address: tullio.florio@unige.it.
  • Amodeo P; Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy. Electronic address: pamodeo@icb.cnr.it.
Bioorg Chem ; 105: 104337, 2020 12.
Article em En | MEDLINE | ID: mdl-33113408
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CXCR4 / Antozoários / Alcaloides Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CXCR4 / Antozoários / Alcaloides Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália