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Rho GTPase regulatory proteins in podocytes.
Matsuda, Jun; Asano-Matsuda, Kana; Kitzler, Thomas M; Takano, Tomoko.
Afiliação
  • Matsuda J; Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.
  • Asano-Matsuda K; Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.
  • Kitzler TM; Research Institute, McGill University Health Centre, Montreal, Quebec, Canada; Division of Medical Genetics, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
  • Takano T; Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: tomoko.takano@mcgill.ca.
Kidney Int ; 99(2): 336-345, 2021 02.
Article em En | MEDLINE | ID: mdl-33122025
The Rho family of small GTPases (Rho GTPases) are the master regulators of the actin cytoskeleton and consist of 22 members. Previous studies implicated dysregulation of Rho GTPases in podocytes in the pathogenesis of proteinuric glomerular diseases. Rho GTPases are primarily regulated by the three families of proteins; guanine nucleotide exchange factors (GEFs; 82 members), GTPase-activating proteins (GAPs; 69 members), and GDP dissociation inhibitors (GDIs; 3 members). Since the regulatory proteins far outnumber their substrate Rho GTPases and act in concert in a cell/context-dependent manner, the upstream regulatory mechanism directing Rho GTPases in podocytes is largely unknown. In this review, we summarize recent advances in the understanding of the role of Rho GTPase regulatory proteins in podocytes, including the known mutations of these proteins that cause proteinuria in humans. We also provide critical appraisal of the in vivo and in vitro studies and identify the knowledge gap in the field that will require further studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Monoméricas de Ligação ao GTP / Podócitos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Kidney Int Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Monoméricas de Ligação ao GTP / Podócitos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Kidney Int Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá