Crystal forms in pharmaceutical applications: olanzapine, a gift to crystal chemistry that keeps on giving.
IUCrJ
; 7(Pt 6): 955-964, 2020 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-33209310
ABSTRACT
This contribution reviews the efforts of many scientists around the world to discover and structurally characterize olanzapine crystal forms, clearing up inconsistencies in the scientific and patent literature and highlighting the challenges in identifying new forms amidst 60+ known polymorphs and solvates. Owing to its remarkable solid-state chemistry, olanzapine has emerged over the last three decades as a popular tool compound for developing new experimental and computational methods for enhanced molecular level understanding of solid-state structure, form diversity and crystallization outcomes. This article highlights the role of olanzapine in advancing the fundamental understanding of crystal forms, interactions within crystal structures, and growth units in molecular crystallization, as well as influencing the way in which drugs are developed today.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
IUCrJ
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos