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Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors.
Huo, Peng-Chao; Hu, Qing; Shu, Sheng; Zhou, Qi-Hang; He, Rong-Jing; Hou, Jie; Guan, Xiao-Qing; Tu, Dong-Zhu; Hou, Xu-Dong; Liu, Peng; Zhang, Nan; Liu, Zhi-Guo; Ge, Guang-Bo.
Afiliação
  • Huo PC; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Hu Q; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Shu S; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zhou QH; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • He RJ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Hou J; Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
  • Guan XQ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Tu DZ; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Hou XD; Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
  • Liu P; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zhang N; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address: zhangnan@zzu.edu.cn.
  • Liu ZG; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: lzgcnu@163.com.
  • Ge GB; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: geguangbo@dicp.ac.cn.
Bioorg Med Chem ; 29: 115853, 2021 01 01.
Article em En | MEDLINE | ID: mdl-33214035
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Chalcona / Inibidores Enzimáticos / Lipase Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Chalcona / Inibidores Enzimáticos / Lipase Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China