Somatic variant analysis of linked-reads sequencing data with Lancet.
Bioinformatics
; 37(13): 1918-1919, 2021 07 27.
Article
em En
| MEDLINE
| ID: mdl-33241313
ABSTRACT
SUMMARY:
We present a new version of the popular somatic variant caller, Lancet, that supports the analysis of linked-reads sequencing data. By seamlessly integrating barcodes and haplotype read assignments within the colored De Bruijn graph local-assembly framework, Lancet computes a barcode-aware coverage and identifies variants that disagree with the local haplotype structure. AVAILABILITY AND IMPLEMENTATION Lancet is implemented in C++ and available for academic and non-commercial research purposes as an open-source package at https//github.com/nygenome/lancet. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Sequenciamento de Nucleotídeos em Larga Escala
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos