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Brief Report: Impact of ART on Maternal Health After Cessation of Breastfeeding.
Brummel, Sean S; Taha, Taha E; Angelidou, Konstantia Nadia; Saidi, Friday; Atuhaire, Patience; Dula, Dingase; Moodley, Dhayendre; Matubu, Allen; Chareka, Gift; Nevrekar, Neetal; Vhembo, Tichaona; Fairlie, Lee; Theron, Gerhard; Mlay, Pendo; George, Kathleen; Basar, Michael; Chakhtoura, Nahida; Browning, Renee; Fowler, Mary Glenn; Currier, Judith S.
Afiliação
  • Brummel SS; The Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Taha TE; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
  • Angelidou KN; The Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Saidi F; University of North Carolina (UNC) Project-Malawi, Kamuzu Central Hospital, Malawi.
  • Atuhaire P; Makerere University -John Hopkins University Research Collaboration (MUJHU CARE LTD) CRS, Kampala, Uganda.
  • Dula D; Johns Hopkins-College of Medicine Research Project, Blantyre, Malawi.
  • Moodley D; Centre for AIDS Research in South Africa and Department of Obstetrics and Gynecology, School of Clinical Medicine, University of KwaZulu Natal, Durban, South Africa.
  • Matubu A; Department of Obstetrics and Gynecology, UZ-UCSF Collaborative Project, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
  • Chareka G; Department of Obstetrics and Gynecology, UZ-UCSF Collaborative Project, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
  • Nevrekar N; Byramjee Jeejeebhoy Government Medical College and Clinical Research Site, Pune, India.
  • Vhembo T; University of Zimbabwe College of Health Sciences-Clinical Trials Research Centre, Harare, Zimbabwe.
  • Fairlie L; Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Theron G; Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Mlay P; Kilimanjaro Christian Medical Center, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
  • George K; Family Health International, Durham, NC.
  • Basar M; Frontier Science and Technology Research Foundation, Amherst, NY.
  • Chakhtoura N; National Institute for Child Health and Human Development, Washington, D.C.
  • Browning R; National Institute of Allergy and Infectious Diseases, Bethesda, MD.
  • Fowler MG; Johns Hopkins U. School of Medicine, Baltimore, MD; and.
  • Currier JS; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
J Acquir Immune Defic Syndr ; 86(4): 450-454, 2021 04 01.
Article em En | MEDLINE | ID: mdl-33273210
ABSTRACT
ABSTRACT IMPAACT PROMISE 1077BF/FF was a sequentially randomized study of pregnant and postpartum women living with HIV to investigate the efficacy and safety of antiretroviral therapy (ART). This Maternal Health Component investigated efficacy for the risk of developing AIDS or death; and safety among women randomized to continue ART (CTART N = 289) or discontinue ART (N = 268) after cessation of breastfeeding or after confirmation of infant infection. No AIDS-defining illnesses were reported during follow-up in either arm. Adverse events of grade 3 or higher were more frequent in the CTART arm [hazard ratio = 1.78, 95% confidence interval (1.05 to 3.02), P-value = 0.03]. The difference in adverse events in the 2 groups was mostly driven by moderate weight loss for women on the CTART arm.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Aleitamento Materno / Infecções por HIV / Transmissão Vertical de Doenças Infecciosas / Fármacos Anti-HIV / Saúde Materna Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Infant / Pregnancy Idioma: En Revista: J Acquir Immune Defic Syndr Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Marrocos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Aleitamento Materno / Infecções por HIV / Transmissão Vertical de Doenças Infecciosas / Fármacos Anti-HIV / Saúde Materna Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Infant / Pregnancy Idioma: En Revista: J Acquir Immune Defic Syndr Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Marrocos