Spatiotemporal regulation of developmental neurite pruning: Molecular and cellular insights from Drosophila models.
Neurosci Res
; 167: 54-63, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33309868
ABSTRACT
Developmental neurite pruning is a process by which neurons selectively eliminate unnecessary processes of axons and/or dendrites without cell death, which shapes the mature wiring of nervous systems. In this sense, developmental neurite pruning requires spatiotemporally precise control of local degradation of cellular components including cytoskeletons and membranes. The Drosophila nervous system undergoes large-scale remodeling, including axon/dendrite pruning, during metamorphosis. In addition to this unique phenomenon in the nervous system, powerful genetic tools make the Drosophila nervous system a sophisticated model to investigate spatiotemporal regulation of neural remodeling. This article reviews recent advances to our understanding of the molecular and cellular mechanisms of developmental axon/dendrite pruning, mainly focusing on studies in Drosophila sensory neurons and mushroom body neurons.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Drosophila
/
Drosophila
Limite:
Animals
Idioma:
En
Revista:
Neurosci Res
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article