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Disseminated Mycobacterium marinum in Human Immunodeficiency Virus Unmasked by Immune Reconstitution Inflammatory Syndrome.
Manion, Maura; Dulanto Chiang, Augusto; Pei, Luxin; Wong, Chun-Shu; Khil, Pavel; Hammoud, Dima A; Anderson, Megan; Laidlaw, Elizabeth; Kuriakose, Safia; Lisco, Andrea; Zelazny, Adrian M; Dekker, John P; Sereti, Irini.
Afiliação
  • Manion M; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Dulanto Chiang A; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Pei L; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Wong CS; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Khil P; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Hammoud DA; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Anderson M; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, Maryland, USA.
  • Laidlaw E; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Kuriakose S; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Lisco A; Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA.
  • Dekker JP; Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
  • Sereti I; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
J Infect Dis ; 224(3): 453-457, 2021 08 02.
Article em En | MEDLINE | ID: mdl-33336253
Distinguishing disseminated Mycobacterium marinum from multifocal cutaneous disease in persons with human immunodeficiency virus/AIDS can present a diagnostic challenge, especially in the context of immune reconstitution inflammatory syndrome (IRIS). In this work, we demonstrate the utility of flow cytometry and whole genome sequencing (WGS) to diagnose disseminated M. marinum unmasked by IRIS following initiation of antiretroviral therapy. Flow cytometry demonstrated robust cytokine production by CD4 T cells in response to stimulation with M. marinum lysate. WGS of isolates from distinct lesions was consistent with clonal dissemination, supporting that preexisting disseminated M. marinum disease was uncovered by inflammatory manifestations, consistent with unmasking mycobacterial IRIS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium marinum / Síndrome Inflamatória da Reconstituição Imune Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium marinum / Síndrome Inflamatória da Reconstituição Imune Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos