Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir.

Wunderling, Klaus; Leopold, Christina; Jamitzky, Isabell; Yaghmour, Mohamed; Zink, Fabian; Kratky, Dagmar; Thiele, Christoph

Wunderling, Klaus; Leopold, Christina; Jamitzky, Isabell; Yaghmour, Mohamed; Zink, Fabian; Kratky, Dagmar; Thiele, Christoph.

Afiliação

Wunderling K; LIMES Life and Medical Sciences Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.
Leopold C; Gottfried Schatz Research Centre, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstrasse 6/6, 8010 Graz, Austria.
Jamitzky I; LIMES Life and Medical Sciences Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.
Yaghmour M; LIMES Life and Medical Sciences Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.
Zink F; LIMES Life and Medical Sciences Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.
Kratky D; Gottfried Schatz Research Centre, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstrasse 6/6, 8010 Graz, Austria; BioTechMed-Graz, Mozartgasse 12, 8010 Graz, Austria.
Thiele C; LIMES Life and Medical Sciences Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany. Electronic address: cthiele@uni-bonn.de.

Mol Metab ; 45: 101150, 2021 03.

Article em En | MEDLINE | ID: mdl-33359403

Assuntos

Diacilglicerol O-Aciltransferase/antagonistas & inibidores; Diacilglicerol O-Aciltransferase/metabolismo; Compostos de Epóxi/farmacologia; Ácidos Graxos/metabolismo; Fígado/metabolismo; Triglicerídeos/metabolismo; Animais; Diacilglicerol O-Aciltransferase/genética; Hepatócitos/metabolismo; Metabolismo dos Lipídeos; Lipogênese; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Oxirredução

Palavras-chave

Etomoxir; MCFA; Metabolic tracing; Teglicar

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Compostos de Epóxi / Diacilglicerol O-Aciltransferase / Ácidos Graxos / Fígado Limite: Animals Idioma: En Revista: Mol Metab Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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