Universal mechanisms for self-termination of rapid cardiac rhythm.
Chaos
; 30(12): 121107, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33380016
ABSTRACT
Excitable media sustain circulating waves. In the heart, sustained circulating waves can lead to serious impairment or even death. To investigate factors affecting the stability of such waves, we have used optogenetic techniques to stimulate a region at the apex of a mouse heart at a fixed delay after the detection of excitation at the base of the heart. For long delays, rapid circulating rhythms can be sustained, whereas for shorter delays, there are paroxysmal bursts of activity that start and stop spontaneously. By considering the dependence of the action potential and conduction velocity on the preceding recovery time using restitution curves, as well as the reduced excitability (fatigue) due to the rapid excitation, we model prominent features of the dynamics including alternation of the duration of the excited phases and conduction times, as well as termination of the bursts for short delays. We propose that this illustrates universal mechanisms that exist in biological systems for the self-termination of such activities.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coração
/
Sistema de Condução Cardíaco
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Chaos
Assunto da revista:
CIENCIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália