Electrochemical sensor based on glassy carbon electrode modified by polymelamine formaldehyde/graphene oxide nanocomposite for ultrasensitive detection of oxycodone.
Mikrochim Acta
; 188(1): 1, 2021 01 02.
Article
em En
| MEDLINE
| ID: mdl-33386503
ABSTRACT
Polymelamine formaldehyde/graphene oxide (PMF/GO) nanocomposite was used, for the first time, to study the ultrasensitive and selective electrochemical detection of oxycodone (OXC). The successful characterization of PMF/GO was verified based on scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), and Raman spectroscopy. The modified GCE (PMF/GO-GCE) proved its electrocatalytic effect on OXC determination according to cyclic, linear sweep, and differential pulse voltammetry (CV, LSV, and DPV) and electrochemical impedance spectroscopy (EIS) studies. The developed sensor under optimal conditions offered a linear relationship in a limited range of 0.01 to 45 µmol L-1 with the limit of detection (LOD) of 2.0 nmol L-1. The proposed PMF/GO-GCE sensor was effectively employed for the OXC detection in human urine and serum samples. Graphical abstract.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxicodona
/
Polímeros
/
Triazinas
/
Nanocompostos
/
Grafite
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Mikrochim Acta
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Irã