Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.

Wu, Danchen; Dasgupta, Asish; Read, Austin D; Bentley, Rachel E T; Motamed, Mehras; Chen, Kuang-Hueih; Al-Qazazi, Ruaa; Mewburn, Jeffrey D; Dunham-Snary, Kimberly J; Alizadeh, Elahe; Tian, Lian; Archer, Stephen L

Wu, Danchen; Dasgupta, Asish; Read, Austin D; Bentley, Rachel E T; Motamed, Mehras; Chen, Kuang-Hueih; Al-Qazazi, Ruaa; Mewburn, Jeffrey D; Dunham-Snary, Kimberly J; Alizadeh, Elahe; Tian, Lian; Archer, Stephen L.

Afiliação

Wu D; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Dasgupta A; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Read AD; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Bentley RET; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Motamed M; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Chen KH; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Al-Qazazi R; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Mewburn JD; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Dunham-Snary KJ; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Alizadeh E; Queen's Cardiopulmonary Unit (QCPU), Department of Medicine, Queen's University, 116 Barrie Street, Kingston, ON, K7L 3J9, Canada.
Tian L; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
Archer SL; Department of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada. Electronic address: stephen.archer@queensu.ca.

Free Radic Biol Med ; 170: 150-178, 2021 07.

Article em En | MEDLINE | ID: mdl-33450375

Assuntos

Hipertensão Pulmonar; Neoplasias; Biologia; Humanos; Peróxido de Hidrogênio; Hipertensão Pulmonar/genética; Neoplasias/genética; Neoplasias/terapia; Oxigênio

Palavras-chave

ABT-199 (Venetoclax); ABT-263 (Navitoclax); B-Cell lymphoma 2 (BCL-2); DNA methylation; DNA methyltransferase (DNMT); Dynamin-related protein 1 (Drp1); Group 1 pulmonary hypertension; Hypoxia-inducible factor 1α (HIF-1α); Hypoxia-inducible factor 2α (HIF-2α); Hypoxic pulmonary vasoconstriction; Mammalian target of rapamycin (mTOR); Mitochondrial calcium uniporter (MCU); Mitochondrial dynamics protein of 49 kDa (MiD49); Mitochondrial dynamics protein of 51 kDa (MiD51); Mitofusin 2 (Mfn2); Mitophagy; Monocrotaline; Oxygen sensing; Peroxisome proliferator-activated receptor Î³ coactivator-1α (PGC-1α); Pyruvate dehydrogenase (PDH); Pyruvate dehydrogenase kinase (PDK); Pyruvate kinase muscle isoform 2 (PKM2); Reactive oxygen species (ROS); Sugen5416; Survivin; miR-138; miR-25; microRNA (miRNA); von hippel-lindau protein (VHL)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertensão Pulmonar / Neoplasias Limite: Humans Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

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