Esterase-Activatable Synthetic M+/Cl- Channel Induces Apoptosis and Disrupts Autophagy in Cancer Cells.
Chemistry
; 26(52): 11946-11949, 2020 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-33463793
ABSTRACT
The formation of a supramolecular synthetic M+/Cl- channel in the membrane phospholipid bilayer has been reported upon activation of a methyl pivalate-linked N1,N3-dialkyl-2-hydroxyisophthalamide by esterases. The channel formation induces apoptosis in cancer cells via the intrinsic pathway. Interestingly, the supramolecular channel was also shown to disrupt autophagy in cancer cells by causing alkalization of lysosomes - a feature that has been confirmed at the cellular and protein level.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esterases
/
Neoplasias
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Índia