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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
Zhang, Zhuming; Connolly, Peter J; Lim, Heng Keang; Pande, Vineet; Meerpoel, Lieven; Teleha, Christopher; Branch, Jonathan R; Ondrus, Janine; Hickson, Ian; Bush, Tammy; Luistro, Leopoldo; Packman, Kathryn; Bischoff, James R; Ibrahim, Salam; Parrett, Christopher; Chong, Yolanda; Gottardis, Marco M; Bignan, Gilles.
Afiliação
  • Zhang Z; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Connolly PJ; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Lim HK; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Pande V; Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Meerpoel L; Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Teleha C; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Branch JR; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Ondrus J; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Hickson I; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Bush T; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Luistro L; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Packman K; Janssen Research and Development, Cambridge, Massachusetts 02142, United States.
  • Bischoff JR; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Ibrahim S; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Parrett C; VWR Avantor, Spring House, Pennsylvania 19477, United States.
  • Chong Y; Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Gottardis MM; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
  • Bignan G; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.
J Med Chem ; 64(2): 909-924, 2021 01 28.
Article em En | MEDLINE | ID: mdl-33470111
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Picolinas / Piperidinas / Neoplasias da Próstata / Piridinas / Compostos de Espiro / Antagonistas de Receptores de Andrógenos / Neoplasias de Próstata Resistentes à Castração / Nitrilas Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Picolinas / Piperidinas / Neoplasias da Próstata / Piridinas / Compostos de Espiro / Antagonistas de Receptores de Andrógenos / Neoplasias de Próstata Resistentes à Castração / Nitrilas Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos