Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui.
J Nat Prod
; 84(2): 544-547, 2021 02 26.
Article
em En
| MEDLINE
| ID: mdl-33496582
ABSTRACT
LCMS analysis of an extract of the New Zealand tunicate Synoicum kuranui showed evidence for numerous new rubrolides. Following a mass spectrometry-guided isolation procedure, new hydrated rubrolides V and W (5 and 6), along with previously reported rubrolide G (3), were isolated and characterized using MS and NMR. The anti-bacterial and cell cytotoxic activity of the compounds were compared to the potent anti-MRSA compound rubrolide A; hydration across the C-5/C-6 bond was shown to abrogate antibacterial activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Urocordados
/
Furanos
Limite:
Animals
/
Humans
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Nova Zelândia