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Effects of Continuous Epidural Injection of Dexamethasone on Blood Glucose, Blood Lipids, Plasma Cortisol and ACTH in Patients With Neuropathic Pain.
Liu, Xiao-Hui; Du, Yu-Min; Cong, Hai-Jing; Liu, Guang-Zhao; Ren, Yu-E.
Afiliação
  • Liu XH; Department of Pain Management, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Du YM; Department of Pain Management, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Cong HJ; Department of Pain Management, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Liu GZ; Department of Pain Management, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Ren YE; Department of Pain Management, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Front Neurol ; 11: 564643, 2020.
Article em En | MEDLINE | ID: mdl-33519661
ABSTRACT

Objective:

To study the effects of continuous epidural injection of dexamethasone on blood glucose, blood lipids, plasma cortisol, and adrenocorticotropic hormone (ACTH) in patients with neuropathic pain.

Methods:

Thirty patients with cervical spondylotic radiculopathy, lumbar disc herniation, herpes pain or postherpetic neuralgia were randomly divided into three groups and were treated with different doses of epidural injection of dexamethasone (Group S with a concentration of 25 µg/mL; Group M with a concentration of 50 µg/mL; Group L with a concentration of 100 µg/mL). Epidural catheterization placement was guided by computed tomography (CT), and was connected to the analgesic pump for 10 days. Visual Analog Score (VAS), fasting blood glucose (FBG), total cholesterol (CHOL), triglyceride (TG), 2 h postprandial blood glucose (2hPG) and the concentrations of cortisol, ACTH were measured before injection (T0), 2, 4, 6, 8, and 10 days during injection (D2, D4, D6, D8, D10), and 7, 14, 21, 28 days (W1, W2, W3, W4) after injection.

Results:

During and after the treatment, VAS score was significantly decreased, and group M and L had the lowest VAS score. The concentrations of cortisol and ACTH were significantly lower during the treatment, but all of them recovered to the normal level after stopping the injection. The treatment did not affect the CHOL and TG concentrations.

Discussion:

Epidural injection of dexamethasone at the concentration of 50 µg/mL is recommended for patients with neuropathic pain because of its good analgesic effect and less adverse effect on blood glucose, plasma cortisol, and ACTH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Qualitative_research Idioma: En Revista: Front Neurol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Qualitative_research Idioma: En Revista: Front Neurol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China