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Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.
Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P; Reinhardt, Hans Christian; Brüning, Jens C; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P; Wunderlich, F Thomas.
Afiliação
  • Kohlhaas V; Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Blakemore SJ; Institute for Genetics, University of Cologne, Cologne, Germany.
  • Al-Maarri M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
  • Nickel N; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Pal M; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
  • Roth A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
  • Hövelmeyer N; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Schäfer SC; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Knittel G; Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Lohneis P; Institute for Genetics, University of Cologne, Cologne, Germany.
  • Nikolic M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
  • Wiederstein JL; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Franitza M; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
  • Georgomonolis T; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
  • Reinart N; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Herling M; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Herling C; Max Planck Institute for Metabolism Research, Cologne, Germany.
  • Hartmann EM; Institute for Genetics, University of Cologne, Cologne, Germany.
  • Rosenwald A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
  • Klapper W; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Büttner R; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
  • Moia R; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
  • Rossi D; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Boldorini R; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Gaidano G; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany.
  • Frenzel LP; Institute of Pathology.
  • Reinhardt HC; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
  • Brüning JC; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Hallek M; Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Krüger M; Institute of Pathology.
  • Peifer M; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Pallasch CP; Department of Translational Genomics, and.
  • Wunderlich FT; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
Blood ; 137(5): 646-660, 2021 02 04.
Article em En | MEDLINE | ID: mdl-33538798
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Linfoma Difuso de Grandes Células B / Proteínas Proto-Oncogênicas c-akt / Receptor Notch1 / Proteínas de Neoplasias Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Linfoma Difuso de Grandes Células B / Proteínas Proto-Oncogênicas c-akt / Receptor Notch1 / Proteínas de Neoplasias Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha