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Association of physical function and performance with peak VO2 in elderly patients with end stage kidney disease.
Myers, Jonathan; Chan, Khin N; Chen, Yu; Lit, Yiming; Massaband, Payam; Kiratli, B Jenny; Tan, Jane C; Rabkin, Ralph.
Afiliação
  • Myers J; Cardiology Division, Veterans Affairs Palo Alto Health Care System, Cardiology 111C, 3801 Miranda Ave, Palo Alto, CA, 94304, USA. drj993@aol.com.
  • Chan KN; Cardiology Division, Stanford University, Stanford, CA, USA. drj993@aol.com.
  • Chen Y; Cardiology Division, Veterans Affairs Palo Alto Health Care System, Cardiology 111C, 3801 Miranda Ave, Palo Alto, CA, 94304, USA.
  • Lit Y; Nephrology Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
  • Massaband P; Cardiology Division, Veterans Affairs Palo Alto Health Care System, Cardiology 111C, 3801 Miranda Ave, Palo Alto, CA, 94304, USA.
  • Kiratli BJ; Nephrology Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
  • Tan JC; Nephrology Division, Stanford University, Stanford, CA, USA.
  • Rabkin R; Radiology Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Aging Clin Exp Res ; 33(10): 2797-2806, 2021 Oct.
Article em En | MEDLINE | ID: mdl-33686542
BACKGROUND: Physical function is impaired in end stage renal disease (ESRD). Various instruments have been used to assess the functional capabilities and health status of patients with ESRD, but it is not known which has the best association with peak VO2. AIMS: To assess the association between functional measures in ESRD. METHODS: Thirty nine elderly ESRD patients were evaluated with commonly used functional, health status, and quality of life measures, including maximal cardiopulmonary exercise testing (CPET), 6-min walk (6MWT), sit-to-stand test (STS), Veterans Specific Activity Questionnaire (VSAQ), upper and lower body strength, pulmonary function tests, and body composition determined by dual X-ray absorptiometry. The association between performance on these functional tools, clinical variables, and exercise test responses was assessed, and a non-exercise test multivariate model was developed to predict peak VO2. RESULTS: Peak VO2 was modestly related to VSAQ score (r = 0.59, p < 0.01), indices of upper and lower body strength (r = 0.45, p < 0.01 for both), and FEV1 (r = 0.51, p < 0.01). Functional and quality of life questionnaires were generally poorly related to one another and to peak VO2. In a multivariate model, 6MWT performance, forced expiratory volume in 1 s (FEV1), and VSAQ score were the best predictors of peak VO2, yielding a multiple R = 0.82, accounting for 67% of the variance in peak VO2. CONCLUSION: Exercise capacity can be reasonably estimated using non-exercise test variables in patients with ESRD, including a symptom questionnaire (VSAQ), 6MWT and FEV1. CLINICAL TRIAL INFORMATION: ClinicalTrials.gov identifier: NCT01990495. Registered Nov 21, 2013.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Falência Renal Crônica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Falência Renal Crônica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos