Cell-Derived Microparticles in Blood Products from Blood Donors Deficient in Glucose-6-Phosphate Dehydrogenase.
Lab Med
; 52(6): 528-535, 2021 Nov 02.
Article
em En
| MEDLINE
| ID: mdl-33693844
ABSTRACT
OBJECTIVE:
To quantitate the microparticles (MPs) in whole blood and blood products obtained from blood donors who are deficient in glucose-6-phosphate dehydrogenase (G6PD).METHODS:
The current study analyzed whole blood and blood components prepared from 49 blood donors with G6PD deficiencies and 98 with G6PD-normal results. Packed red blood cells (PRBCs), platelet concentrate (PC), and plasma were prepared according to transfusion laboratory procedures. MP concentrations were determined using a flow cytometer.RESULTS:
Blood components prepared from donors with G6PD deficiency were characterized by higher red blood cell-derived MP (RMP) concentration in PRBCs (25,526 vs 18,738 particles/µL) but lower concentrations of platelet-derived MPs (PMPs; in whole blood and PC), leukocyte-derived MPs (LMP; in whole blood and plasma) and total MP (in PC), compared with those from donors with G6PD-normal test results.CONCLUSIONS:
These results suggest that differences in G6PD status may account for variation in RMP levels during processing.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Glucosefosfato Desidrogenase
Limite:
Humans
Idioma:
En
Revista:
Lab Med
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Tailândia