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A new anti-austerity agent, 4'-O-methylgrynullarin from Derris scandens induces PANC-1 human pancreatic cancer cell death under nutrition starvation via inhibition of Akt/mTOR pathway.
Sun, Sijia; Dibwe, Dya Fita; Kim, Min Jo; Omar, Ashraf M; Phan, Nguyen Duy; Fujino, Haruka; Pongterdsak, Nusrin; Chaithatwatthana, Kritsaya; Phrutivorapongkul, Ampai; Awale, Suresh.
Afiliação
  • Sun S; Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • Dibwe DF; Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • Kim MJ; Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • Omar AM; Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • Phan ND; Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • Fujino H; Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • Pongterdsak N; Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Chaithatwatthana K; Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Phrutivorapongkul A; Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Awale S; Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: suresh@inm.u-toyama.ac.jp.
Bioorg Med Chem Lett ; 40: 127967, 2021 05 15.
Article em En | MEDLINE | ID: mdl-33753259
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Transdução de Sinais / Morte Celular / Hemiterpenos / Isoflavonas / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Transdução de Sinais / Morte Celular / Hemiterpenos / Isoflavonas / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão