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Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice.
Ali, Tahir; Hannaoui, Samia; Nemani, Satish; Tahir, Waqas; Zemlyankina, Irina; Cherry, Pearl; Shim, Su Yeon; Sim, Valerie; Schaetzl, Hermann M; Gilch, Sabine.
Afiliação
  • Ali T; Calgary Prion Research Unit, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
  • Hannaoui S; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Nemani S; Calgary Prion Research Unit, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
  • Tahir W; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Zemlyankina I; Department of Medicine - Division of Neurology, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, Canada.
  • Cherry P; Calgary Prion Research Unit, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
  • Shim SY; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Sim V; Calgary Prion Research Unit, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
  • Schaetzl HM; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Gilch S; Calgary Prion Research Unit, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
Acta Neuropathol Commun ; 9(1): 58, 2021 04 01.
Article em En | MEDLINE | ID: mdl-33795005
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Creutzfeldt-Jakob / Proteínas PrPSc / Ciclopropanos / Benzoxazinas / Alcinos / Inibidores das Enzimas do Citocromo P-450 / Colesterol 24-Hidroxilase Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Creutzfeldt-Jakob / Proteínas PrPSc / Ciclopropanos / Benzoxazinas / Alcinos / Inibidores das Enzimas do Citocromo P-450 / Colesterol 24-Hidroxilase Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá