Synthesis, antioxidant activity and bioinformatics studies of L-3-hydroxytyrosine templated N-alkyl/aryl substituted urea/thioureas.

Kollu, Umapriya; Avula, Vijaya Kumar Reddy; Vallela, Swetha; Pasupuleti, Visweswara Rao; Zyryanov, Grigory Vasilievich; Neelam, Yugandhar Sreedhar; Chamarthi, Naga Raju

Kollu, Umapriya; Avula, Vijaya Kumar Reddy; Vallela, Swetha; Pasupuleti, Visweswara Rao; Zyryanov, Grigory Vasilievich; Neelam, Yugandhar Sreedhar; Chamarthi, Naga Raju.

Afiliação

Kollu U; Department of Chemistry, Sri Venkateswara University, Tirupati 517502, A.P., India.
Avula VKR; Chemical Engineering Institute, Ural Federal University, Yekaterinburg 620002, Russian Federation.
Vallela S; Chemical Engineering Institute, Ural Federal University, Yekaterinburg 620002, Russian Federation.
Pasupuleti VR; Department of Biomedical Sciences and Therapeutics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia.
Zyryanov GV; Chemical Engineering Institute, Ural Federal University, Yekaterinburg 620002, Russian Federation; Ural Division of the Russian Academy of Sciences, I. Ya. Postovskiy Institute of Organic Synthesis, 22 S. Kovalevskoy Street, Yekaterinburg 620219, Russian Federation.
Neelam YS; Department of Chemistry, Sri Venkateswara University, Tirupati 517502, A.P., India.
Chamarthi NR; Department of Chemistry, Sri Venkateswara University, Tirupati 517502, A.P., India. Electronic address: rajuchamarthi10@gmail.com.

Bioorg Chem ; 111: 104837, 2021 06.

Article em En | MEDLINE | ID: mdl-33812281

Assuntos

Antioxidantes/farmacologia; Biologia Computacional; Tirosina/farmacologia; Ureia/farmacologia; Antioxidantes/síntese química; Antioxidantes/química; Compostos de Bifenilo/antagonistas & inibidores; Relação Dose-Resposta a Droga; Compostos Férricos/antagonistas & inibidores; Simulação de Acoplamento Molecular; Estrutura Molecular; Picratos/antagonistas & inibidores; Relação Estrutura-Atividade; Tirosina/síntese química; Tirosina/química; Ureia/análogos & derivados; Ureia/química

Palavras-chave

1N8Q enzymatic protein; 3NRZ enzymatic protein; ADMET properties; Antioxidant activity; Bioactivity & toxicity studies; Isocyanates/Isothiocyanates; L-3-hydroxytyrosine; Molecular docking studies; QSAR studies; Urea/thiourea derivatives

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tirosina / Ureia / Biologia Computacional / Antioxidantes Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google