CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.

Yin, Wei; Li, Yihong; Song, Yan; Zhang, Jiarui; Wu, Chao; Chen, Yu; Miao, Ying; Lin, Changdong; Lin, Yuli; Yan, Dapeng; Chen, Jianfeng; He, Rui

Yin, Wei; Li, Yihong; Song, Yan; Zhang, Jiarui; Wu, Chao; Chen, Yu; Miao, Ying; Lin, Changdong; Lin, Yuli; Yan, Dapeng; Chen, Jianfeng; He, Rui.

Afiliação

Yin W; Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Li Y; Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Song Y; Department of Laboratory Animal Science, Fudan University, Shanghai, 200032, China.
Zhang J; Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Wu C; Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118.
Chen Y; Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Miao Y; Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Lin C; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Lin Y; State Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Yan D; Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Chen J; Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
He R; State Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

Proc Natl Acad Sci U S A ; 118(16)2021 04 20.

Article em En | MEDLINE | ID: mdl-33846258

Assuntos

Ativação de Macrófagos/imunologia; Neoplasias/imunologia; Receptores CCR/metabolismo; Animais; Linfócitos T CD8-Positivos/imunologia; China; Feminino; Imunização; Ativação de Macrófagos/fisiologia; Masculino; Melanoma/metabolismo; Camundongos; NF-kappa B/metabolismo; Neoplasias/genética; Receptores CCR/genética; Transdução de Sinais; Linfócitos T/metabolismo; Receptor 4 Toll-Like/imunologia; Receptor 4 Toll-Like/metabolismo; Macrófagos Associados a Tumor/imunologia; Macrófagos Associados a Tumor/metabolismo

Palavras-chave

CCRL2; TLR4; antitumor T-cell immunity; tumor associated macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CCR / Ativação de Macrófagos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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