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Direct and Indirect Modulation of T Cells by VEGF-A Counteracted by Anti-Angiogenic Treatment.
Bourhis, Morgane; Palle, Juliette; Galy-Fauroux, Isabelle; Terme, Magali.
Afiliação
  • Bourhis M; Université de Paris, PARCC, INSERM, Paris, France.
  • Palle J; Université de Paris, PARCC, INSERM, Paris, France.
  • Galy-Fauroux I; Department of GI Oncology, AP-HP, Hôpital Européen Georges-Pompidou, Paris, France.
  • Terme M; Université de Paris, PARCC, INSERM, Paris, France.
Front Immunol ; 12: 616837, 2021.
Article em En | MEDLINE | ID: mdl-33854498
Vascular endothelial growth factor A is known to play a central role in tumor angiogenesis. Several studies showed that VEGF-A is also an immunosuppressive factor. In tumor-bearing hosts, VEGF-A can modulate immune cells (DC, MDSC, TAM) to induce the accumulation of regulatory T-cells while simultaneously inhibiting T-cell functions. Furthermore, VEGFR-2 expression on activated T-cells and FoxP3high regulatory T-cells also allow a direct effect of VEGF-A. Anti-angiogenic agents targeting VEGF-A/VEGFR contribute to limit tumor-induced immunosuppression. Based on interesting preclinical studies, many clinical trials have been conducted to investigate the efficacy of anti-VEGF-A/VEGFR treatments combined with immune checkpoint blockade leading to the approvement of these associations in different tumor locations. In this review, we focus on the impact of VEGF-A on immune cells especially regulatory and effector T-cells and different therapeutic strategies to restore an antitumor immunity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Inibidores da Angiogênese / Fator A de Crescimento do Endotélio Vascular / Imunomodulação Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Inibidores da Angiogênese / Fator A de Crescimento do Endotélio Vascular / Imunomodulação Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França