Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.

Tan, Michele S Y; Koussis, Konstantinos; Withers-Martinez, Chrislaine; Howell, Steven A; Thomas, James A; Hackett, Fiona; Knuepfer, Ellen; Shen, Min; Hall, Matthew D; Snijders, Ambrosius P; Blackman, Michael J

Tan, Michele S Y; Koussis, Konstantinos; Withers-Martinez, Chrislaine; Howell, Steven A; Thomas, James A; Hackett, Fiona; Knuepfer, Ellen; Shen, Min; Hall, Matthew D; Snijders, Ambrosius P; Blackman, Michael J.

Afiliação

Tan MSY; Malaria Biochemistry Laboratory, The Francis Crick Institute, London, UK.
Koussis K; Malaria Biochemistry Laboratory, The Francis Crick Institute, London, UK.
Withers-Martinez C; Malaria Biochemistry Laboratory, The Francis Crick Institute, London, UK.
Howell SA; Protein Analysis and Proteomics Platform, The Francis Crick Institute, London, UK.
Thomas JA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Hackett F; Malaria Biochemistry Laboratory, The Francis Crick Institute, London, UK.
Knuepfer E; Department of Pathobiology and Population Sciences, Royal Veterinary College, Hertfordshire, UK.
Shen M; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA.
Hall MD; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA.
Snijders AP; Protein Analysis and Proteomics Platform, The Francis Crick Institute, London, UK.
Blackman MJ; Malaria Biochemistry Laboratory, The Francis Crick Institute, London, UK.

EMBO J ; 40(11): e107226, 2021 06 01.

Article em En | MEDLINE | ID: mdl-33932049

Assuntos

Antimaláricos/farmacologia; Cisteína Proteases/metabolismo; Plasmodium falciparum/metabolismo; Inibidores de Proteases/farmacologia; Proteínas de Protozoários/metabolismo; Células Cultivadas; Eritrócitos/metabolismo; Eritrócitos/parasitologia; Humanos; Plasmodium falciparum/efeitos dos fármacos; Plasmodium falciparum/patogenicidade; Proteólise; Proteínas de Protozoários/antagonistas & inibidores; Serina Proteases/metabolismo; Espectrina/metabolismo

Palavras-chave

Plasmodium falciparum; cofactor; egress; malaria; protease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Inibidores de Proteases / Proteínas de Protozoários / Cisteína Proteases / Antimaláricos Limite: Humans Idioma: En Revista: EMBO J Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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