Specific activation of glycolytic enzyme enolase 2 in BRAF V600E-mutated colorectal cancer.

Yukimoto, Ryohei; Nishida, Naohiro; Hata, Tsuyoshi; Fujino, Shiki; Ogino, Takayuki; Miyoshi, Norikatsu; Takahashi, Hidekazu; Uemura, Mamoru; Satoh, Taroh; Hirofumi, Yamamoto; Mizushima, Tsunekazu; Doki, Yuichiro; Eguchi, Hidetoshi

Yukimoto, Ryohei; Nishida, Naohiro; Hata, Tsuyoshi; Fujino, Shiki; Ogino, Takayuki; Miyoshi, Norikatsu; Takahashi, Hidekazu; Uemura, Mamoru; Satoh, Taroh; Hirofumi, Yamamoto; Mizushima, Tsunekazu; Doki, Yuichiro; Eguchi, Hidetoshi.

Afiliação

Yukimoto R; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Nishida N; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Hata T; Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Suita, Japan.
Fujino S; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Ogino T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Miyoshi N; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Takahashi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Uemura M; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Satoh T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Hirofumi Y; Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Suita, Japan.
Mizushima T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Doki Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.

Cancer Sci ; 112(7): 2884-2894, 2021 Jul.

Article em En | MEDLINE | ID: mdl-33934428

Assuntos

Neoplasias Colorretais/enzimologia; Fosfopiruvato Hidratase/metabolismo; Proteínas Proto-Oncogênicas B-raf/metabolismo; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Movimento Celular/genética; Proliferação de Células/genética; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Neoplasias Colorretais/patologia; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Bases de Dados Factuais; Progressão da Doença; Ativação Enzimática; Expressão Gênica; Técnicas de Silenciamento de Genes; Humanos; Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Fosfopiruvato Hidratase/antagonistas & inibidores; Fosfopiruvato Hidratase/genética; Prognóstico; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores; Proteínas Proto-Oncogênicas B-raf/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas Proto-Oncogênicas c-fos/metabolismo; Interferência de RNA; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo; Vemurafenib/farmacologia

Palavras-chave

BRAF V600E-mutated colorectal cancer; ENO2; FOSL1; glycolysis; metabolic genes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfopiruvato Hidratase / Neoplasias Colorretais / Proteínas Proto-Oncogênicas B-raf Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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