Fetal serotoninergic transplants in the fourth ventricle of adult rodents reverse sleep disturbances induced by neonatal administration of 5,7-dihydroxytryptamine.
Neurosci Lett
; 89(1): 108-13, 1988 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-3399137
ABSTRACT
Rats received a neonatal (at 4 days of age) intracisternal injection of 5,7-dihydroxytryptamine which eliminates serotonin (5-HT) throughout adulthood. Sleep recordings, performed on these rats at adult age, demonstrated significant decreases in paradoxical sleep. Dissociated fetal 5-HT cell suspensions transplanted in the IVth ventricle of these rats restored paradoxical sleep. However, fetal neuronal noradrenergic or cholinergic transplants did not restore paradoxical sleep. These results suggest that paradoxical sleep is directly or indirectly mediated through serotoninergic mechanisms.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos do Sono-Vigília
/
Núcleos da Rafe
/
Serotonina
/
Ventrículos Cerebrais
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
França