Early decreases in cortical mid-gamma peaks coincide with the onset of motor deficits and precede exaggerated beta build-up in rat models for Parkinson's disease.

Brazhnik, Elena; Novikov, Nikolay; McCoy, Alex J; Ilieva, Neda M; Ghraib, Marian W; Walters, Judith R

Brazhnik, Elena; Novikov, Nikolay; McCoy, Alex J; Ilieva, Neda M; Ghraib, Marian W; Walters, Judith R.

Afiliação

Brazhnik E; Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3702, United States of America.
Novikov N; Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3702, United States of America.
McCoy AJ; Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3702, United States of America.
Ilieva NM; Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3702, United States of America.
Ghraib MW; Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3702, United States of America.
Walters JR; Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3702, United States of America. Electronic address: waltersj@ninds.nih.gov.

Neurobiol Dis ; 155: 105393, 2021 07.

Article em En | MEDLINE | ID: mdl-34000417

Assuntos

Ritmo beta/fisiologia; Ritmo Gama/fisiologia; Córtex Motor/fisiopatologia; Transtornos Motores/fisiopatologia; Oxidopamina/toxicidade; Transtornos Parkinsonianos/fisiopatologia; Animais; Ritmo beta/efeitos dos fármacos; Antagonistas dos Receptores de Dopamina D2/administração & dosagem; Teste de Esforço/métodos; Ritmo Gama/efeitos dos fármacos; Masculino; Córtex Motor/efeitos dos fármacos; Transtornos Motores/induzido quimicamente; Transtornos Parkinsonianos/induzido quimicamente; Ratos; Ratos Long-Evans; Receptores de Dopamina D1/antagonistas & inibidores

Palavras-chave

Basal ganglia; Beta oscillations; Dopamine antagonists; Gait; Gamma oscillations; Local field potentials; Motor cortex; Movement disorders; Parkinson's disease; Rodent models; Substantia nigra pars reticulata

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo beta / Oxidopamina / Transtornos Parkinsonianos / Ritmo Gama / Transtornos Motores / Córtex Motor Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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