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The Nexus of cfDNA and Nuclease Biology.
Han, Diana S C; Lo, Y M Dennis.
Afiliação
  • Han DSC; Centre for Novostics, Hong Kong Science Park, New Territories, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
  • Lo YMD; Centre for Novostics, Hong Kong Science Park, New Territories, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; State Key Laboratory in Translational Oncology and Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China. Electronic address: loym@cuhk.edu.hk.
Trends Genet ; 37(8): 758-770, 2021 08.
Article em En | MEDLINE | ID: mdl-34006390
Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive waste products of cell death but could have a physiological and pathological function in inflammation and autoimmunity. The balance of cfDNA generation and clearance may thus be vital in health and disease. In particular, plasma nuclease activity has been linked to multiple pathologies including cancer and systemic lupus erythematosus (SLE) and associated with profound changes in the nonrandom fragmentation of cfDNA. Lastly, in this review, we explore the effects of DNA fragmentation factor B (DFFB), DNASE1L3, and DNASE1 on cfDNA levels and their fragmentomic profiles, and what these recent insights reveal about the biology of cfDNA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desoxirribonucleases / Desoxirribonuclease I / Endodesoxirribonucleases / Proteínas de Ligação a Poli-ADP-Ribose / Ácidos Nucleicos Livres Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desoxirribonucleases / Desoxirribonuclease I / Endodesoxirribonucleases / Proteínas de Ligação a Poli-ADP-Ribose / Ácidos Nucleicos Livres Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China