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Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
Tichenor, Mark S; Wiener, John J M; Rao, Navin L; Pooley Deckhut, Charlotte; Barbay, J Kent; Kreutter, Kevin D; Bacani, Genesis M; Wei, Jianmei; Chang, Leon; Murrey, Heather E; Wang, Weixue; Ahn, Kay; Huber, Michael; Rex, Elizabeth; Coe, Kevin J; Wu, JieJun; Seierstad, Mark; Bembenek, Scott D; Leonard, Kristi A; Lebsack, Alec D; Venable, Jennifer D; Edwards, James P.
Afiliação
  • Tichenor MS; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Wiener JJM; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Rao NL; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Pooley Deckhut C; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Barbay JK; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Kreutter KD; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Bacani GM; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Wei J; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Chang L; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Murrey HE; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Wang W; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Ahn K; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Huber M; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Rex E; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Coe KJ; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Wu J; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Seierstad M; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Bembenek SD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Leonard KA; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Lebsack AD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Venable JD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Edwards JP; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
ACS Med Chem Lett ; 12(5): 782-790, 2021 May 13.
Article em En | MEDLINE | ID: mdl-34055226
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos