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A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.
Grandjean, Philippe; Hu, Howard; Till, Christine; Green, Rivka; Bashash, Morteza; Flora, David; Tellez-Rojo, Martha Maria; Song, Peter X K; Lanphear, Bruce; Budtz-Jørgensen, Esben.
Afiliação
  • Grandjean P; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Hu H; Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Till C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Green R; Faculty of Health, York University, Ontario, Canada.
  • Bashash M; Faculty of Health, York University, Ontario, Canada.
  • Flora D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Tellez-Rojo MM; Faculty of Health, York University, Ontario, Canada.
  • Song PXK; Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico.
  • Lanphear B; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Budtz-Jørgensen E; Faculty of Health Sciences, Simon Fraser University, British Columbia, Canada.
Risk Anal ; 42(3): 439-449, 2022 03.
Article em En | MEDLINE | ID: mdl-34101876
As a guide to establishing a safe exposure level for fluoride exposure in pregnancy, we applied benchmark dose modeling to data from two prospective birth cohort studies. We included mother-child pairs from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) cohort in Mexico and the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort in Canada. Maternal urinary fluoride concentrations (U-F, in mg/L, creatinine-adjusted) were measured in urine samples obtained during pregnancy. Children were assessed for intelligence quotient (IQ) at age 4 (n = 211) and between six and 12 years (n = 287) in the ELEMENT cohort, and three to four years (n = 407) in the MIREC cohort. We calculated covariate-adjusted regression coefficients and their standard errors to assess the association of maternal U-F concentrations with children's IQ measures. Assuming a benchmark response of 1 IQ point, we derived benchmark concentrations (BMCs) and benchmark concentration levels (BMCLs). No deviation from linearity was detected in the dose-response relationships, but boys showed lower BMC values than girls. Using a linear slope for the joint cohort data, the BMC for maternal U-F associated with a 1-point decrease in IQ scores was 0.31 mg/L (BMCL, 0.19 mg/L) for the youngest boys and girls in the two cohorts, and 0.33 mg/L (BMCL, 0.20 mg/L) for the MIREC cohort and the older ELEMENT children. Thus, the joint data show a BMCL in terms of the adjusted U-F concentrations in the pregnant women of approximately 0.2 mg/L. These results can be used to guide decisions on preventing excess fluoride exposure in pregnant women.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Fluoretos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Risk Anal Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Fluoretos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Risk Anal Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos