Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.

Deng, Youchao; Deng, Sunbin; Ho, Yi-Hsun; Gardner, Sarah M; Huang, Zhi; Marmorstein, Ronen; Huang, Rong

Deng, Youchao; Deng, Sunbin; Ho, Yi-Hsun; Gardner, Sarah M; Huang, Zhi; Marmorstein, Ronen; Huang, Rong.

Afiliação

Deng Y; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Deng S; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ho YH; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Gardner SM; Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Huang Z; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Marmorstein R; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Huang R; Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

J Med Chem ; 64(12): 8263-8271, 2021 06 24.

Article em En | MEDLINE | ID: mdl-34110812

Assuntos

Coenzima A/farmacologia; Inibidores Enzimáticos/farmacologia; Acetiltransferase N-Terminal D/antagonistas & inibidores; Peptídeos/farmacologia; Sequência de Aminoácidos; Linhagem Celular Tumoral; Coenzima A/síntese química; Coenzima A/metabolismo; Cristalografia por Raios X; Desenho de Fármacos; Ensaios Enzimáticos; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/metabolismo; Humanos; Cinética; Estrutura Molecular; Acetiltransferase N-Terminal D/química; Acetiltransferase N-Terminal D/metabolismo; Peptídeos/síntese química; Peptídeos/metabolismo; Ligação Proteica; Relação Estrutura-Atividade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Coenzima A / Inibidores Enzimáticos / Acetiltransferase N-Terminal D Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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