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The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.
Copin, Richard; Baum, Alina; Wloga, Elzbieta; Pascal, Kristen E; Giordano, Stephanie; Fulton, Benjamin O; Zhou, Anbo; Negron, Nicole; Lanza, Kathryn; Chan, Newton; Coppola, Angel; Chiu, Joyce; Ni, Min; Wei, Yi; Atwal, Gurinder S; Hernandez, Annabel Romero; Saotome, Kei; Zhou, Yi; Franklin, Matthew C; Hooper, Andrea T; McCarthy, Shane; Hamon, Sara; Hamilton, Jennifer D; Staples, Hilary M; Alfson, Kendra; Carrion, Ricardo; Ali, Shazia; Norton, Thomas; Somersan-Karakaya, Selin; Sivapalasingam, Sumathi; Herman, Gary A; Weinreich, David M; Lipsich, Leah; Stahl, Neil; Murphy, Andrew J; Yancopoulos, George D; Kyratsous, Christos A.
Afiliação
  • Copin R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Baum A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Wloga E; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Pascal KE; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Giordano S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Fulton BO; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Zhou A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Negron N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Lanza K; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Chan N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Coppola A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Chiu J; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Ni M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Wei Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Atwal GS; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Hernandez AR; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Saotome K; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Zhou Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Franklin MC; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Hooper AT; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • McCarthy S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Hamon S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Hamilton JD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Staples HM; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Alfson K; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Carrion R; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
  • Ali S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Norton T; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Somersan-Karakaya S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Sivapalasingam S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Herman GA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Weinreich DM; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Lipsich L; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Stahl N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Murphy AJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Yancopoulos GD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
  • Kyratsous CA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: christos.kyratsous@regeneron.com.
Cell ; 184(15): 3949-3961.e11, 2021 07 22.
Article em En | MEDLINE | ID: mdl-34161776
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 / Anticorpos Monoclonais / Mutação Tipo de estudo: Clinical_trials Limite: Animals / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 / Anticorpos Monoclonais / Mutação Tipo de estudo: Clinical_trials Limite: Animals / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos