Discovery of a size-record breaking green-emissive fluorophore: small, smaller, HINA.
Chem Sci
; 12(4): 1392-1397, 2020 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-34163902
ABSTRACT
Astonishingly, 3-hydroxyisonicotinealdehyde (HINA) is despite its small size a green-emitting push-pull fluorophore in water (QY of 15%) and shows ratiometric emission response to biological relevant pH differences (pK a2 â¼ 7.1). Moreover, HINA is the first small-molecule fluorophore reported that possesses three distinctly emissive protonation states. This fluorophore can be used in combination with metal complexes for fluorescent-based cysteine detection in aqueous media, and is readily taken up by cells. The theoretical description of HINA's photophysics remains challenging, even when computing Franck-Condon profiles via coupled-cluster calculations, making HINA an interesting model for future method development.
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01-internacional
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MEDLINE
Idioma:
En
Revista:
Chem Sci
Ano de publicação:
2020
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Article