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Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes.
Schromm, Andra B; Paulowski, Laura; Kaconis, Yani; Kopp, Franziska; Koistinen, Max; Donoghue, Annemarie; Keese, Susanne; Nehls, Christian; Wernecke, Julia; Garidel, Patrick; Sevcsik, Eva; Lohner, Karl; Sanchez-Gomez, Susana; Martinez-de-Tejada, Guillermo; Brandenburg, Klaus; Brameshuber, Mario; Schütz, Gerhard J; Andrä, Jörg; Gutsmann, Thomas.
Afiliação
  • Schromm AB; Division of Immunobiophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany; aschromm@fz-borstel.de.
  • Paulowski L; Division of Immunobiophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Kaconis Y; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Kopp F; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Koistinen M; Division of Immunobiophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Donoghue A; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Keese S; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Nehls C; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Wernecke J; Division of Immunobiophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Garidel P; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Sevcsik E; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, D-23845 Borstel, Germany.
  • Lohner K; Deutsches Elektronen-Synchrotron, D-22607 Hamburg, Germany.
  • Sanchez-Gomez S; Biophysikalische Chemie, Martin-Luther-Universität Halle-Wittenberg, D-06108 Halle, Germany.
  • Martinez-de-Tejada G; Institute of Applied Physics at TU Wien, Vienna 1040, Austria.
  • Brandenburg K; Institute of Molecular Biosciences, Biophysics Division, University of Graz, A-8010 Graz, Austria.
  • Brameshuber M; BioTechMed-Graz, A-8010 Graz, Austria.
  • Schütz GJ; Department of Microbiology and Parasitology, University of Navarra, E-31008 Pamplona, Spain.
  • Andrä J; Department of Microbiology and Parasitology, University of Navarra, E-31008 Pamplona, Spain.
  • Gutsmann T; Navarra Institute for Health Research, E-31008 Pamplona, Spain.
Proc Natl Acad Sci U S A ; 118(27)2021 07 06.
Article em En | MEDLINE | ID: mdl-34183393

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimixina B / Testes de Neutralização / Membrana Celular / Lipopolissacarídeos / Catelicidinas / Interações Hospedeiro-Patógeno Limite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimixina B / Testes de Neutralização / Membrana Celular / Lipopolissacarídeos / Catelicidinas / Interações Hospedeiro-Patógeno Limite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article