Follicular T-Helper Cells in Marginal Zone Lymphoma: Evidence of an Organoid Immune Response.
Am J Dermatopathol
; 43(12): e197-e203, 2021 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-34231493
ABSTRACT
INTRODUCTION:
Primary cutaneous marginal zone B-cell lymphoma (MZL) follows an indolent clinical course. Histopathologically, there is a polymorphous infiltrate that includes small lymphocyte-like and centrocyte-like B cells and plasma cells usually with a substantial T-cell fraction. Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder, in which the signature cells have a follicular T-helper (TFH) phenotype and are admixed with numerous B cells. Thus, both present histologies of combined B-cell and T-cell infiltrates and represent differential diagnoses. The presence of TFH in MZL has yet to be elucidated.METHODS:
Forty-one biopsies from 40 cases of MZL and 7 cases of lymphoid hyperplasia cutis (LCH) were stained with antibodies to follicular T-helper cells, including Bcl-6, PD-1, ICOS, and CD10, as part of their diagnostic workup, were reviewed, and the stained slides were evaluated semiquantitively. Five reactive lymph nodes were also evaluated as controls.RESULTS:
All cases of MZL and LCH contained TFH, albeit usually in low proportions. There were repeated differences in levels of expression between TFH markers, with PD1 and Bcl-6 being the most prevalent. The pattern of involvement in MZL and LCH closely mirrored that observed in the reactive lymph nodes.CONCLUSION:
MZL includes TFH cells, similar to reactive lymph nodes, and a complexity of cell types. This provides evidence of an organoid immune response challenging its simple categorization as a malignancy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organoides
/
Linfoma de Zona Marginal Tipo Células B
/
Células T Auxiliares Foliculares
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Am J Dermatopathol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Portugal