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A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke.
Yamazawa, Toshiko; Kobayashi, Takuya; Kurebayashi, Nagomi; Konishi, Masato; Noguchi, Satoru; Inoue, Takayoshi; Inoue, Yukiko U; Nishino, Ichizo; Mori, Shuichi; Iinuma, Hiroto; Manaka, Noriaki; Kagechika, Hiroyuki; Uryash, Arkady; Adams, Jose; Lopez, Jose R; Liu, Xiaochen; Diggle, Christine; Allen, Paul D; Kakizawa, Sho; Ikeda, Keigo; Lin, Bangzhong; Ikemi, Yui; Nunomura, Kazuto; Nakagawa, Shinsaku; Sakurai, Takashi; Murayama, Takashi.
Afiliação
  • Yamazawa T; Department of Molecular Physiology, The Jikei University School of Medicine, Tokyo, Japan. toshiko1998@jikei.ac.jp.
  • Kobayashi T; Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.
  • Kurebayashi N; Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.
  • Konishi M; Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.
  • Noguchi S; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Inoue T; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Inoue YU; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Nishino I; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Mori S; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
  • Iinuma H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
  • Manaka N; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
  • Kagechika H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
  • Uryash A; Department of Neonatology, Mount Sinai Medical Center, Miami, FL, USA.
  • Adams J; Department of Neonatology, Mount Sinai Medical Center, Miami, FL, USA.
  • Lopez JR; Department of Research, Mount Sinai Medical Center, Miami, FL, USA.
  • Liu X; Leeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds, UK.
  • Diggle C; Leeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds, UK.
  • Allen PD; Leeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James's University Hospital, Leeds, UK.
  • Kakizawa S; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
  • Ikeda K; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.
  • Lin B; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.
  • Ikemi Y; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.
  • Nunomura K; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.
  • Nakagawa S; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.
  • Sakurai T; Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.
  • Murayama T; Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan. takashim@juntendo.ac.jp.
Nat Commun ; 12(1): 4293, 2021 07 13.
Article em En | MEDLINE | ID: mdl-34257294
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Cálcio / Canal de Liberação de Cálcio do Receptor de Rianodina / Hipertermia Maligna Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Cálcio / Canal de Liberação de Cálcio do Receptor de Rianodina / Hipertermia Maligna Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão