Comparison of intravenous glucagon and dextrose in treatment of severe hypoglycemia in an accident and emergency department.
Diabetes Care
; 10(6): 712-5, 1987.
Article
em En
| MEDLINE
| ID: mdl-3428048
ABSTRACT
Hypoglycemia is a serious problem in insulin-treated diabetic patients. In this study the efficacy of intravenous glucagon (1 mg) was compared with that of intravenous dextrose (25 g) in the treatment of hypoglycemia in insulin-treated patients attending an accident and emergency department. In addition, the prevailing glycemic control of these patients was compared with patients routinely attending a diabetic outpatient clinic. Both intravenous glucagon and dextrose were effective in the treatment of hypoglycemic coma. There was a difference in the glycemic profile after intravenous glucagon compared with intravenous dextrose, and recovery of a normal level of consciousness after glucagon was slower than after dextrose (6.5 vs. 4.0 min, respectively; P less than .001), although the average duration of hypoglycemic coma was 1.4 h. The glucagon- and dextrose-treated groups had significantly lower HbA1 than comparable patients routinely attending the clinic (9.5 +/- 0.8 vs. 12.0 +/- 3.8%, respectively; P less than .001). In view of the ease of administration and the small risk of vascular and extravascular complications, intravenous glucagon appears to be a useful alternative to intravenous dextrose in the treatment of severe hypoglycemia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glucagon
/
Diabetes Mellitus Tipo 1
/
Emergências
/
Glucose
/
Hipoglicemia
Limite:
Humans
Idioma:
En
Revista:
Diabetes Care
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Reino Unido