The emerging roles of absent in melanoma 2 (AIM2) inflammasome in central nervous system disorders.
Neurochem Int
; 149: 105122, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34284076
ABSTRACT
As a double-stranded DNA (dsDNA) sensor, the PYHIN family member absent in melanoma 2 (AIM2) is an essential component of the inflammasome families. Activation of AIM2 by dsDNA leads to the assembly of cytosolic multimolecular complexes termed the AIM2 inflammasome, resulting in activation of caspase-1, the maturation and secretion of pro-inflammatory cytokines interleukin (IL)-1ß and IL-18, and pyroptosis. Multiple central nervous system (CNS) diseases are accompanied by immune responses and inflammatory cascade. As the resident macrophage cells, microglia cells act as the first and main form of active immune defense in the CNS. AIM2 is highly expressed in microglia as well as astrocytes and neurons and is essential in neurodevelopment. In this review, we highlight the recent progress on the role of AIM2 inflammasome in CNS disorders, including cerebral stroke, brain injury, neuropsychiatric disease, neurodegenerative diseases, and glioblastoma.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Central
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Mediadores da Inflamação
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Proteínas de Ligação a DNA
Limite:
Animals
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Humans
Idioma:
En
Revista:
Neurochem Int
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China