Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics.
Rev Physiol Biochem Pharmacol
; 183: 135-155, 2022.
Article
em En
| MEDLINE
| ID: mdl-34291318
ABSTRACT
Cancer is a collection of diseases caused by specific changes at the genomic level that support cell proliferation indefinitely. Traditionally, ion channels are known to control a variety of cellular processes including electrical signal generation and transmission, secretion, and contraction by controlling ionic gradients. However, recent studies had brought to light important facts on ion channels in cancer biology.In this review we discuss the mechanism linking potassium or chloride ion channel activity to biochemical pathways controlling proliferation in cancer cells and the potential advantages of targeting ion channels as an anticancer therapeutic option.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Rev Physiol Biochem Pharmacol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Canadá