IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.

Prelli Bozzo, Caterina; Nchioua, Rayhane; Volcic, Meta; Koepke, Lennart; Krüger, Jana; Schütz, Desiree; Heller, Sandra; Stürzel, Christina M; Kmiec, Dorota; Conzelmann, Carina; Müller, Janis; Zech, Fabian; Braun, Elisabeth; Groß, Rüdiger; Wettstein, Lukas; Weil, Tatjana; Weiß, Johanna; Diofano, Federica; Rodríguez Alfonso, Armando A; Wiese, Sebastian; Sauter, Daniel; Münch, Jan; Goffinet, Christine; Catanese, Alberto; Schön, Michael; Boeckers, Tobias M; Stenger, Steffen; Sato, Kei; Just, Steffen; Kleger, Alexander; Sparrer, Konstantin M J; Kirchhoff, Frank

Prelli Bozzo, Caterina; Nchioua, Rayhane; Volcic, Meta; Koepke, Lennart; Krüger, Jana; Schütz, Desiree; Heller, Sandra; Stürzel, Christina M; Kmiec, Dorota; Conzelmann, Carina; Müller, Janis; Zech, Fabian; Braun, Elisabeth; Groß, Rüdiger; Wettstein, Lukas; Weil, Tatjana; Weiß, Johanna; Diofano, Federica; Rodríguez Alfonso, Armando A; Wiese, Sebastian; Sauter, Daniel; Münch, Jan; Goffinet, Christine; Catanese, Alberto; Schön, Michael; Boeckers, Tobias M; Stenger, Steffen; Sato, Kei; Just, Steffen; Kleger, Alexander; Sparrer, Konstantin M J; Kirchhoff, Frank.

Afiliação

Prelli Bozzo C; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Nchioua R; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Volcic M; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Koepke L; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Krüger J; Department of Internal Medicine I, Ulm University Medical Center, Ulm, Germany.
Schütz D; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Heller S; Department of Internal Medicine I, Ulm University Medical Center, Ulm, Germany.
Stürzel CM; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Kmiec D; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Conzelmann C; Department of Infectious Diseases, King's College London, London, UK.
Müller J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Zech F; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Braun E; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Groß R; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Wettstein L; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Weil T; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Weiß J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Diofano F; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Rodríguez Alfonso AA; Department of Internal Medicine II (Cardiology), Ulm University, Ulm, Germany.
Wiese S; Core Facility of Functional Peptidomics, Ulm University Medical Center, Ulm, Germany.
Sauter D; Core Unit of Mass Spectrometry and Proteomics, Ulm University Medical Center, Ulm, Germany.
Münch J; Core Unit of Mass Spectrometry and Proteomics, Ulm University Medical Center, Ulm, Germany.
Goffinet C; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Catanese A; Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Schön M; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Boeckers TM; Institute of Virology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Stenger S; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Sato K; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Just S; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Kleger A; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ulm University, Ulm, Germany.
Sparrer KMJ; Institute of Medical Microbiology and Hygiene, Ulm University Medical Center, Ulm, Germany.
Kirchhoff F; Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Nat Commun ; 12(1): 4584, 2021 07 28.

Article em En | MEDLINE | ID: mdl-34321474

Assuntos

Enzima de Conversão de Angiotensina 2/genética; Antígenos de Diferenciação/genética; Proteínas de Membrana/genética; Proteínas de Ligação a RNA/genética; SARS-CoV-2/genética; Glicoproteína da Espícula de Coronavírus/genética; Sequência de Aminoácidos; Enzima de Conversão de Angiotensina 2/antagonistas & inibidores; Enzima de Conversão de Angiotensina 2/metabolismo; Anticorpos Neutralizantes/farmacologia; Antígenos de Diferenciação/metabolismo; Sítios de Ligação; COVID-19/virologia; Regulação da Expressão Gênica; Interações Hospedeiro-Patógeno/efeitos dos fármacos; Interações Hospedeiro-Patógeno/genética; Humanos; Interferon beta/farmacologia; Proteínas de Membrana/antagonistas & inibidores; Proteínas de Membrana/metabolismo; Ligação Proteica; Domínios e Motivos de Interação entre Proteínas; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Proteínas de Ligação a RNA/antagonistas & inibidores; Proteínas de Ligação a RNA/metabolismo; SARS-CoV-2/efeitos dos fármacos; SARS-CoV-2/metabolismo; Alinhamento de Sequência; Homologia de Sequência de Aminoácidos; Glicoproteína da Espícula de Coronavírus/metabolismo; Ligação Viral/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Diferenciação / Proteínas de Ligação a RNA / Glicoproteína da Espícula de Coronavírus / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Proteínas de Membrana Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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