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Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids.
Hamdan, Firas; Ylösmäki, Erkko; Chiaro, Jacopo; Giannoula, Yvonne; Long, Maeve; Fusciello, Manlio; Feola, Sara; Martins, Beatriz; Feodoroff, Michaela; Antignani, Gabriella; Russo, Salvatore; Kari, Otto; Lee, Moon; Järvinen, Petrus; Nisen, Harry; Kreutzman, Anna; Leusen, Jeanette; Mustjoki, Satu; McWilliams, Thomas G; Grönholm, Mikaela; Cerullo, Vincenzo.
Afiliação
  • Hamdan F; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
  • Ylösmäki E; TRIMM, Translational Immunology Research Program, University of Helsinki, Helsinki, Uusimaa, Finland.
  • Chiaro J; Drug Delivery, Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
  • Giannoula Y; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
  • Long M; TRIMM, Translational Immunology Research Program, University of Helsinki, Helsinki, Uusimaa, Finland.
  • Fusciello M; Drug Delivery, Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
  • Feola S; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
  • Martins B; TRIMM, Translational Immunology Research Program, University of Helsinki, Helsinki, Uusimaa, Finland.
  • Feodoroff M; Drug Delivery, Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
  • Antignani G; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
  • Russo S; Translational Stem Cell Biology & Metabolism Program, Research Programs Unit, Department of Anatomy, Faculty of Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
  • Kari O; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
  • Lee M; TRIMM, Translational Immunology Research Program, University of Helsinki, Helsinki, Uusimaa, Finland.
  • Järvinen P; Drug Delivery, Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
  • Nisen H; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
  • Kreutzman A; TRIMM, Translational Immunology Research Program, University of Helsinki, Helsinki, Uusimaa, Finland.
  • Leusen J; Drug Delivery, Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
  • Mustjoki S; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
  • McWilliams TG; TRIMM, Translational Immunology Research Program, University of Helsinki, Helsinki, Uusimaa, Finland.
  • Grönholm M; Drug Delivery, Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
  • Cerullo V; Laboratory of Immunovirotherapy, Drug Research Program, University of Helsinki Faculty of Pharmacy, Helsinki, Uusimaa, Finland.
J Immunother Cancer ; 9(8)2021 08.
Article em En | MEDLINE | ID: mdl-34362830
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Viral Oncolítica / Inibidores de Checkpoint Imunológico / Imunoterapia / Neoplasias Limite: Animals / Female / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Finlândia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Viral Oncolítica / Inibidores de Checkpoint Imunológico / Imunoterapia / Neoplasias Limite: Animals / Female / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Finlândia