CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-&#954;B Pathway.

Armento, Angela; Schmidt, Tiziana L; Sonntag, Inga; Merle, David A; Jarboui, Mohamed Ali; Kilger, Ellen; Clark, Simon J; Ueffing, Marius

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway.

Armento, Angela; Schmidt, Tiziana L; Sonntag, Inga; Merle, David A; Jarboui, Mohamed Ali; Kilger, Ellen; Clark, Simon J; Ueffing, Marius.

Afiliação

Armento A; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
Schmidt TL; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
Sonntag I; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
Merle DA; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
Jarboui MA; Department of Ophthalmology, Medical University of Graz, 8036 Graz, Austria.
Kilger E; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
Clark SJ; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
Ueffing M; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.

Int J Mol Sci ; 22(16)2021 Aug 13.

Article em En | MEDLINE | ID: mdl-34445430

Assuntos

Citocinas/metabolismo; Inativação Gênica; Degeneração Macular/genética; Epitélio Pigmentado da Retina/imunologia; Linhagem Celular; Fator H do Complemento/genética; Proteínas do Sistema Complemento/metabolismo; Citocinas/genética; Regulação da Expressão Gênica; Humanos; Degeneração Macular/imunologia; Modelos Biológicos; NF-kappa B/genética; NF-kappa B/metabolismo; Epitélio Pigmentado da Retina/metabolismo; Transdução de Sinais

Palavras-chave

NF-κB pathway; age-related macular degeneration (AMD); complement factor H (CFH); cytokines; inflammation; retinal pigment epithelium (RPE) cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Inativação Gênica / Epitélio Pigmentado da Retina / Degeneração Macular Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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