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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton, Leah G; Soliman, Ahmed; von Zweydorf, Felix; Kentros, Michalis; Manschwetus, Jascha T; Hall, Scotty; Gilsbach, Bernd; Ho, Franz Y; Athanasopoulos, Panagiotis S; Singh, Ranjan K; LeClair, Timothy J; Versées, Wim; Raimondi, Francesco; Herberg, Friedrich W; Gloeckner, Christian Johannes; Rideout, Hardy; Kortholt, Arjan; Kennedy, Eileen J.
Afiliação
  • Helton LG; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, United States.
  • Soliman A; Department of Cell Biochemistry, University of Groningen, 9747 Groningen, The Netherlands.
  • von Zweydorf F; DZNE, German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.
  • Kentros M; Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece.
  • Manschwetus JT; Department of Biochemistry, Institute for Biology, University of Kassel, 34132, Kassel, Germany.
  • Hall S; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, United States.
  • Gilsbach B; DZNE, German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.
  • Ho FY; Department of Cell Biochemistry, University of Groningen, 9747 Groningen, The Netherlands.
  • Athanasopoulos PS; Department of Cell Biochemistry, University of Groningen, 9747 Groningen, The Netherlands.
  • Singh RK; VIB-VUB Center for Structural Biology, Pleinlaan 2, 1050 Brussels, Belgium.
  • LeClair TJ; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
  • Versées W; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, United States.
  • Raimondi F; VIB-VUB Center for Structural Biology, Pleinlaan 2, 1050 Brussels, Belgium.
  • Herberg FW; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
  • Gloeckner CJ; Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore, 56126, Pisa, Italy.
  • Rideout H; Department of Biochemistry, Institute for Biology, University of Kassel, 34132, Kassel, Germany.
  • Kortholt A; DZNE, German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.
  • Kennedy EJ; Core Facility for Medical Bioanalytics, Center for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, Germany.
ACS Chem Biol ; 16(11): 2326-2338, 2021 11 19.
Article em En | MEDLINE | ID: mdl-34496561
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Peptídeos / Inibidores Enzimáticos / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Peptídeos / Inibidores Enzimáticos / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos