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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Cosden, Mali; Jinn, Sarah; Yao, Lihang; Gretzula, Cheryl A; Kandebo, Monika; Toolan, Dawn; Hatcher, Nathan G; Ma, Lei; Lemaire, Wei; Adam, Gregory C; Burlein, Christine; Minnick, Christina; Flick, Rose; Watt, Marla L; Mulhearn, James; Fraley, Mark; Drolet, Robert E; Marcus, Jacob N; Smith, Sean M.
Afiliação
  • Cosden M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Jinn S; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Yao L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Gretzula CA; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Kandebo M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Toolan D; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Hatcher NG; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Ma L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Lemaire W; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.
  • Adam GC; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.
  • Burlein C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.
  • Minnick C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.
  • Flick R; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.
  • Watt ML; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.
  • Mulhearn J; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States.
  • Fraley M; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States.
  • Drolet RE; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Marcus JN; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.
  • Smith SM; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States. Electronic address: sean_smith2@merck.com.
Neurobiol Dis ; 159: 105507, 2021 11.
Article em En | MEDLINE | ID: mdl-34509608
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzoxazóis / Glicoesfingolipídeos / Alfa-Sinucleína / Neurônios Dopaminérgicos / Sinucleinopatias / Glucosilceramidase / Glucosiltransferases / Lisossomos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzoxazóis / Glicoesfingolipídeos / Alfa-Sinucleína / Neurônios Dopaminérgicos / Sinucleinopatias / Glucosilceramidase / Glucosiltransferases / Lisossomos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos