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Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men.
Masterson, John M; Bui, Chau; Zhang, Yi; Yuan, Xiaopen; Huynh, Carissa; Jawanda, Harneet; Hasan, Wohaib; Tourtellotte, Warren; Luthringer, Daniel; Garcia, Maurice M.
Afiliação
  • Masterson JM; Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Bui C; Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Zhang Y; Biobank and Translational Research, Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Yuan X; Biobank and Translational Research, Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Huynh C; Biobank and Translational Research, Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Jawanda H; Biobank and Translational Research, Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Hasan W; Biobank and Translational Research, Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Tourtellotte W; Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Luthringer D; Biobank and Translational Research, Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Garcia MM; Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Andrologia ; 53(11): e14186, 2021 Dec.
Article em En | MEDLINE | ID: mdl-34514615
ABSTRACT
It has been proposed that men hospitalised with COVID-19 be treated with oestrogen or progesterone to improve COVID-19 outcomes. Transgender women (male-to-female) are routinely treated with oestrogen or oestrogen +progesterone for feminisation which provides a model for the effect of feminising hormones on testicular tissue. Our goal was to analyse differences in ACE-2 expression in testicles of trans-women taking oestrogen or oestrogen +progesterone. Orchiectomy specimens were collected from trans-women undergoing gender-affirming surgery, who were taking oestrogen or oestrogen+progesterone preoperatively. For controls, we used benign orchiectomy specimens from cis-gender men. All specimens were stained with H&E, Trichrome (fibrosis), insulin-like 3 antibody (Leydig cell) and ACE-2 IHC. Cells per high-powered field were counted by cell type (Leydig, Sertoli and Germ). Stain intensity was rated on a 0-2 scale. On immunohistochemistry staining for Leydig cells and ACE-2 staining, the oestrogen+progesterone cohort had fewer Leydig cells compared with controls. The oestrogen+progesterone cohort also had greater degree of tissue fibrosis compared with controls and the oestrogen cohort. This work supports the hopeful possibility that a short course of progesterone (or oestrogen+progesterone) could downregulate ACE-2 to protect men from COVID-19 infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estrogênios / Enzima de Conversão de Angiotensina 2 Limite: Female / Humans / Male Idioma: En Revista: Andrologia Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estrogênios / Enzima de Conversão de Angiotensina 2 Limite: Female / Humans / Male Idioma: En Revista: Andrologia Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos