Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.

Delpech, Jean-Christophe; Pathak, Dhruba; Varghese, Merina; Kalavai, Srinidhi Venkatesan; Hays, Emma C; Hof, Patrick R; Johnson, W Evan; Ikezu, Seiko; Medalla, Maria; Luebke, Jennifer I; Ikezu, Tsuneya

Delpech, Jean-Christophe; Pathak, Dhruba; Varghese, Merina; Kalavai, Srinidhi Venkatesan; Hays, Emma C; Hof, Patrick R; Johnson, W Evan; Ikezu, Seiko; Medalla, Maria; Luebke, Jennifer I; Ikezu, Tsuneya.

Afiliação

Delpech JC; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Pathak D; University of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000 Bordeaux, France.
Varghese M; Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Kalavai SV; Nash Family Department of Neuroscience, Friedman Brain Institute, and Ronald C. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hays EC; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Hof PR; Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Johnson WE; Nash Family Department of Neuroscience, Friedman Brain Institute, and Ronald C. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ikezu S; Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.
Medalla M; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Luebke JI; Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Ikezu T; Center for Systems Neuroscience, Boston University, Boston, MA, USA.

Sci Transl Med ; 13(611): eabe8455, 2021 Sep 15.

Article em En | MEDLINE | ID: mdl-34524859

Assuntos

Córtex Entorrinal; Hipocampo; Animais; Camundongos; Neurônios

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Entorrinal / Hipocampo Limite: Animals Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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