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Natural sensory context drives diverse brain-wide activity during C. elegans mating.
Susoy, Vladislav; Hung, Wesley; Witvliet, Daniel; Whitener, Joshua E; Wu, Min; Park, Core Francisco; Graham, Brett J; Zhen, Mei; Venkatachalam, Vivek; Samuel, Aravinthan D T.
Afiliação
  • Susoy V; Department of Physics, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: vladislav_susoy@fas.harvard.edu.
  • Hung W; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Witvliet D; Department of Physics, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
  • Whitener JE; Department of Physics, Northeastern University, Boston, MA 02115, USA.
  • Wu M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Park CF; Department of Physics, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
  • Graham BJ; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
  • Zhen M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Venkatachalam V; Department of Physics, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Northeastern University, Boston, MA 02115, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: v.venkatachalam@northeastern.edu.
  • Samuel ADT; Department of Physics, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: samuel@physics.harvard.edu.
Cell ; 184(20): 5122-5137.e17, 2021 09 30.
Article em En | MEDLINE | ID: mdl-34534446
ABSTRACT
Natural goal-directed behaviors often involve complex sequences of many stimulus-triggered components. Understanding how brain circuits organize such behaviors requires mapping the interactions between an animal, its environment, and its nervous system. Here, we use brain-wide neuronal imaging to study the full performance of mating by the C. elegans male. We show that as mating unfolds in a sequence of component behaviors, the brain operates similarly between instances of each component but distinctly between different components. When the full sensory and behavioral context is taken into account, unique roles emerge for each neuron. Functional correlations between neurons are not fixed but change with behavioral dynamics. From individual neurons to circuits, our study shows how diverse brain-wide dynamics emerge from the integration of sensory perception and motor actions in their natural context.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sensação / Comportamento Sexual Animal / Encéfalo / Caenorhabditis elegans Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sensação / Comportamento Sexual Animal / Encéfalo / Caenorhabditis elegans Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article