Melatonin potentiates the cytotoxic effect of Neratinib in HER2<sup>+</sup> breast cancer through promoting endocytosis and lysosomal degradation of HER2.

Liu, Zundong; Sang, Xiaolin; Wang, Min; Liu, Yichao; Liu, Jiao; Wang, Xuefei; Liu, Pixu; Cheng, Hailing

Melatonin potentiates the cytotoxic effect of Neratinib in HER2⁺ breast cancer through promoting endocytosis and lysosomal degradation of HER2.

Liu, Zundong; Sang, Xiaolin; Wang, Min; Liu, Yichao; Liu, Jiao; Wang, Xuefei; Liu, Pixu; Cheng, Hailing.

Afiliação

Liu Z; Cancer Institute, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Sang X; Cancer Institute, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Wang M; Cancer Institute, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Liu Y; Cancer Institute, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Liu J; Cancer Institute, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Wang X; Cancer Institute, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Liu P; The Second Hospital of Dalian Medical University, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, China. pixu_liu@163.com.
Cheng H; Cancer Institute, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China. hailingcheng_dmu@163.com.

Oncogene ; 40(44): 6273-6283, 2021 11.

Article em En | MEDLINE | ID: mdl-34556812

Assuntos

Neoplasias da Mama/tratamento farmacológico; Melatonina/administração & dosagem; Quinolinas/administração & dosagem; Receptor ErbB-2/química; Receptor ErbB-2/metabolismo; Animais; Neoplasias da Mama/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Sinergismo Farmacológico; Endocitose; Feminino; Humanos; Lisossomos/metabolismo; Células MCF-7; Melatonina/farmacologia; Camundongos; Proteólise; Quinolinas/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Neoplasias da Mama / Receptor ErbB-2 / Melatonina Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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